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Parkinson's Disease Fast Facts

Epidemiology

  • PD affects approximately 127,000 people in the UK which equates to 1 in 500 people living with the disease1
  • PD is more prevalent in people over 50 years of age but 1 in 20 people with PD are under the age of 401
  • PD is the second most common neurological disorder in the UK2
  • The annual incidence of PD each year is 4 to 20 per 100,000 individual3
  • The risks of developing PD increase with age; figures estimate that 2 in 100 people over the age of 80 develop some signs of the disease3

Burden of disease

  • The most common motor symptoms of PD are tremor, rigidity, slowness of movement and postural instability4
  • Symptoms are divided into 2 main categories: motor symptoms and non-motor symptoms1
  • As PD develops it can lead to impaired cognitive function. It is estimated that 30% of PD patients also go on to develop senile dementia3
  • Disease progression can also lead to increased depressive symptomology with research suggesting that 20-45% of people living with PD develop depression5
  • PD imposes significant direct costs on public services in the UK:6
  • Each of the UKs 25,000 General Practitioners has approximately four PD patients in their care
  • 38% of National Health Service costs and 34% of social services costs are PD related

Treatment for PD
Treatments which help to alleviate the symptoms of PD include:4

  • Levodopa – which increases dopamine in the brain
  • Dopamine agonists – these agents mimic dopamine and include rotigotine, apomorphine, bromocriptine, pramipexole and ropinirole
  • MAO-B and COMT inhibitors – these agents inhibit dopamine breakdown and include selegiline, entacapone and tolcapone

References

1. Parkinson’s UK http://www.parkinsons.org.uk/about-parkinsons/what-is-parkinsons.aspx (accessed June 2012)

2. Department for Work and Pensions (DWP) Website http://www.dwp.gov.uk/publications/specialist-guides/medical-conditions/a-z-of-medical-conditions/parkinsons-disease/prevalence-pd.shtml (accessed June 2012)

3. Netdoctor.co.uk http://www.netdoctor.co.uk/diseases/facts/parkinson.htm (accessed June 2012)

4. National Institute of Neurological Disorders and Stroke http://www.ninds.nih.gov/disorders/parkinsons_disease/detail_parkinsons_disease.htm (accessed June 2012)

5. Rickards H. J. Depression in neurological disorders: Parkinson’s Disease, Multiple Sclerosis and Stroke. Neurol Neurosurg Psychiatry 2005;76(Suppl I):i48–i52.

6. Findley et al. Direct Economic Impact of Parkinson’s Disease: A Research Survey in the United Kingdom. Movement Disorders 2003;18:1139–118.

Aug 2012 - UK/12NE0077a